Association between prognosis and SEMA4D/Plexin-B1 expression in various malignancies: A meta-analysis.

ABSTRACT:

Introduction

SEMA4D and its high affinity receptor Plexin-B1 showed a promising prognosis prediction for carcinoma patients in recent studies, we performed a meta-analysis to evaluate the prognostic role of them in various malignancies.

Methods

A systematic literature search was performed in PubMed, Embase, Web of Science, and CNKI from inception till July 2017. Eligible studies were identified by different reviewers. Hazard ratios (HRs)/related ratios (RRs) and their corresponding 95% confidence intervals (CIs) were extracted to investigate the relevance between malignancies prognosis and SEMA4D/Plexin-B1.

Results

Around 2638 patients from 14 studies were included in this meta-analysis. High expression of SEMA4D was significantly associated with overall survival (OS)

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6407964 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature