Anticoagulation in atrial fibrillation and cognitive decline: A systematic review and meta-analysis.

ABSTRACT:

Background

It is well known that atrial fibrillation (AF) carried a high risk of cognitive decline, which is independent of stroke or transient ischemic attack (TIA). Whether anticoagulation is associated with reduced risk of cognitive decline in participants with AF still remains controversial. We conducted a systematic review and meta-analysis to explore the effect of anticoagulation on the risk of cognitive decline in patients with AF.

Methods

We systematically searched the PubMed, Embase and the Cochrane Database for eligible studies published up to January 2018. Risk ratios (RR) with 95% confidence interval (CI) for cognitive decline were extracted, and pooled estimations were calculated using the fixed effects model. Subgroup analyses were further performed.

Results

SUBMITTER: Zeng D 

PROVIDER: S-EPMC6408007 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature