Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome: A systematic review and meta-analysis.

ABSTRACT:

Background

Recent studies indicate that gut microbiota disorders potentially contribute to the pathogenesis of irritable bowel syndrome (IBS), which can be partly reflected by fecal short-chain fatty acids (SCFAs) generated from gut microbiota. Previous studies on SCFA alterations in patients with IBS have yielded conflicting results. No prior systematic review has been conducted on the alterations in fecal SCFAs in IBS patients.

Aims

We performed a meta-analysis to explore and clarify alterations in fecal SCFAs in IBS patients.

Methods

Case-control studies, randomized controlled trials (RCTs), and self-controlled studies were identified through electronic database searches. The standardized mean difference (SMD) with 95% confidence interval (CI) in fecal SCFA levels

SUBMITTER: Sun Q 

PROVIDER: S-EPMC6408019 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature