Proton pump inhibitor use and risk of dementia: Systematic review and meta-analysis.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) are an established kind of drugs used to the treatment of most acid-related diseases. Some prospective studies have noticed that PPI use was associated with increased dementia risk. However, the results of those studies were inconsistent and controversial. This meta-analysis aims to determine the association of PPI use and risk of dementia among older people.

Methods

Relevant articles were systematically identified by searching the PubMed, EMBASE, and Cochrane Library databases from inception to February 2018. Cohort studies that reported the risk of dementia or Alzheimer's disease (AD) among PPI users compared with non-PPI users were included. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS). The publication

SUBMITTER: Li M 

PROVIDER: S-EPMC6408083 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature