Habitual consumption of long-chain n-3 PUFAs and fish attenuates genetically associated long-term weight gain.

ABSTRACT:

Background

A growing amount of data suggests that n-3 (ω-3) polyunsaturated fatty acid (PUFA) intake may modify the genetic association with weight change.

Objectives

We aimed to prospectively test interactions of habitual consumption of n-3 PUFAs or fish, the major food source, with overall genetic susceptibility on long-term weight change.

Design

Gene-diet interactions were examined in 11,330 women from the Nurses' Health Study (NHS), 6773 men from the Health Professionals Follow-Up Study (HPFS), and 6254 women from the Women's Health Initiative (WHI).

Results

In the NHS and HPFS cohorts, food-sourced long-chain n-3 PUFA intake showed directionally consistent interactions with genetic risk score on long-term changes in BMI (P-interaction = 0.01 in the HPFS, 0

SUBMITTER: Huang T 

PROVIDER: S-EPMC6408206 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature