Randomized double-blind, placebo-controlled trial evaluating oral glutamine on radiation-induced oral mucositis and dermatitis in head and neck cancer patients.

ABSTRACT:

Background

Glutamine is the primary fuel for the gastrointestinal epithelium and maintains the mucosal structure. Oncologists frequently encounter oral mucositis, which can cause unplanned breaks in radiotherapy (RT).

Objectives

The aim of this study was to explore the association between oral glutamine and acute toxicities in patients with head and neck cancer undergoing RT.

Methods

This was a parallel, double-blind, randomized, placebo-controlled Phase III trial conducted in a university hospital. A central randomization center used computer-generated tables to allocate interventions to 71 patients with stages I-IV head and neck cancers. The patients, care providers, and investigators were blinded to the group assignment. Eligible patients received either oral gluta

SUBMITTER: Huang CJ 

PROVIDER: S-EPMC6408208 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature