Serum metabolites associated with dietary protein intake: results from the Modification of Diet in Renal Disease (MDRD) randomized clinical trial.

ABSTRACT:

Background

Accurate assessment of dietary intake is essential, but self-report of dietary intake is prone to measurement error and bias. Discovering metabolic consequences of diets with lower compared with higher protein intake could elucidate new, objective biomarkers of protein intake.

Objectives

The goal of this study was to identify serum metabolites associated with dietary protein intake.

Methods

Metabolites were measured with the use of untargeted, reverse-phase ultra-performance liquid chromatography-tandem mass spectrometry quantification in serum specimens collected at the 12-mo follow-up visit in the Modification of Diet in Renal Disease (MDRD) Study from 482 participants in study A (glomerular filtration rate: 25-55 mL · min-1 · 1.73 m-2) and 192 participan

SUBMITTER: Rebholz CM 

PROVIDER: S-EPMC6408209 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature