Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths.

ABSTRACT:

Objective

Childhood irritability is a common, impairing problem with changing age-related manifestations that predict long-term adverse outcomes. However, more investigation of overall and age-specific neural correlates is needed. Because youths with irritability exhibit exaggerated responses to frustrating stimuli, the authors used a frustration functional MRI (fMRI) paradigm to examine associations between irritability and neural activation and tested the moderating effect of age.

Method

The authors studied a transdiagnostic sample of 195 youths with varying levels of irritability (disruptive mood dysregulation disorder, N=52; anxiety disorder, N=42; attention deficit hyperactivity disorder, N=40; and healthy volunteers, N=61). Irritability was measured by parent and child

SUBMITTER: Tseng WL 

PROVIDER: S-EPMC6408218 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature