Ontology highlight
ABSTRACT:
SUBMITTER: Wu P
PROVIDER: S-EPMC6408234 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Molecular cell 20190130 5
TCRs recognize cognate pMHCs to initiate T cell signaling and adaptive immunity. Mechanical force strengthens TCR-pMHC interactions to elicit agonist-specific catch bonds to trigger TCR signaling, but the underlying dynamic structural mechanism is unclear. We combined steered molecular dynamics (SMD) simulation, single-molecule biophysical approaches, and functional assays to collectively demonstrate that mechanical force induces conformational changes in pMHCs to enhance pre-existing contacts a ...[more]