Coordinated Emergence of Hippocampal Replay and Theta Sequences during Post-natal Development.

ABSTRACT: Hippocampal place cells encode an animal's current position in space during exploration [1]. During sleep, hippocampal network activity recapitulates patterns observed during recent experience: place cells with overlapping spatial fields show a greater tendency to co-fire ("reactivation") [2], and temporally ordered and compressed sequences of place cell firing observed during wakefulness are reinstated ("replay") [3-5]. Reactivation and replay may underlie memory consolidation [6-10]. Compressed sequences of place cell firing also occur during exploration: during each cycle of the theta oscillation, the set of active place cells shifts from those signaling positions behind to those signaling positions ahead of an animal's current location [11, 12]. These "theta sequences" have been linked

SUBMITTER: Muessig L 

PROVIDER: S-EPMC6408330 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature