IPIP27 Coordinates PtdIns(4,5)P₂ Homeostasis for Successful Cytokinesis.

ABSTRACT: During cytokinesis, an actomyosin contractile ring drives the separation of the two daughter cells. A key molecule in this process is the inositol lipid PtdIns(4,5)P₂, which recruits numerous factors to the equatorial region for contractile ring assembly. Despite the importance of PtdIns(4,5)P₂ in cytokinesis, the regulation of this lipid in cell division remains poorly understood. Here, we identify a role for IPIP27 in mediating cellular PtdIns(4,5)P₂ homeostasis. IPIP27 scaffolds the inositol phosphatase oculocerebrorenal syndrome of Lowe (OCRL) by coupling it to endocytic BAR domain proteins. Loss of IPIP27 causes accumulation of PtdIns(4,5)P₂ on aberrant endomembrane vacuoles, mislocalization of the cytokinetic machinery, and extensive cortic

SUBMITTER: Carim SC 

PROVIDER: S-EPMC6408333 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature