Investigation of strontium transport and strontium quantification in cortical rat bone by time-of-flight secondary ion mass spectrometry.

ABSTRACT: Next-generation bone implants will be functionalized with drugs for stimulating bone growth. Modelling of drug release by such functionalized biomaterials and drug dispersion into bone can be used as predicting tool for biomaterials testing in future. Therefore, the determination of experimental parameters to describe and simulate drug release in bone is essential. Here, we focus on Sr²⁺ transport and quantification in cortical rat bone. Sr²⁺ dose-dependently stimulates bone-building osteoblasts and inhibits bone-resorbing osteoclasts. It should be preferentially applied in the case of bone fracture in the context of osteoporotic bone status. Transport properties of cortical rat bone were investigated by dipping experiments of bone sections in aqueous Sr²⁺

SUBMITTER: Kern C 

PROVIDER: S-EPMC6408337 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature