Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice.

ABSTRACT: Chromodomain Y (CDY) is one of the candidate genes for male dyszoospermia related to Y chromosome microdeletion (YCM). However, the function of CDY in regulating spermatogenesis has not been completely determined. The mouse Cdyl (CDY-like) gene is the homolog of human CDY. In the present study, we generated a germline conditional knockout (cKO) model of mouse Cdyl. Significantly, the Cdyl^cKO male mice suffered from the defects in spermatogonia maintenance and spermatozoon morphogenesis, demonstrating teratozoospermia and a progressive infertility phenotype in early adulthood. Importantly, patterns of specific histone methylation and acetylation were extensively changed, which disturbed the transcriptome in Cdyl^cKO testis. Our findings indicated that Cdyl is crucial fo

SUBMITTER: Xia X 

PROVIDER: S-EPMC6408431 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature