CHD7 promotes glioblastoma cell motility and invasiveness through transcriptional modulation of an invasion signature.

ABSTRACT: Chromatin remodeler proteins exert an important function in promoting dynamic modifications in the chromatin architecture, performing a central role in regulating gene transcription. Deregulation of these molecular machines may lead to striking perturbations in normal cell function. The CHD7 gene is a member of the chromodomain helicase DNA-binding family and, when mutated, has been shown to be the cause of the CHARGE syndrome, a severe developmental human disorder. Moreover, CHD7 has been described to be essential for neural stem cells and it is also highly expressed or mutated in a number of human cancers. However, its potential role in glioblastoma has not yet been tested. Here, we show that CHD7 is up-regulated in human glioma tissues and we demonstrate that CHD7 knockout (KO) in LN-22

SUBMITTER: Machado RAC 

PROVIDER: S-EPMC6408455 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature