Inter-annual variation in seasonal dengue epidemics driven by multiple interacting factors in Guangzhou, China.

ABSTRACT: Vector-borne diseases display wide inter-annual variation in seasonal epidemic size due to their complex dependence on temporally variable environmental conditions and other factors. In 2014, Guangzhou, China experienced its worst dengue epidemic on record, with incidence exceeding the historical average by two orders of magnitude. To disentangle contributions from multiple factors to inter-annual variation in epidemic size, we fitted a semi-mechanistic model to time series data from 2005-2015 and performed a series of factorial simulation experiments in which seasonal epidemics were simulated under all combinations of year-specific patterns of four time-varying factors: imported cases, mosquito density, temperature, and residual variation in local conditions not explicitly represented in

SUBMITTER: Oidtman RJ 

PROVIDER: S-EPMC6408462 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature