Cytotoxicity profiling of deep eutectic solvents to human skin cells.

ABSTRACT: The tailor-made character of deep eutectic solvents (DES) turns them very attractive to be used in several applications, including in health-related areas such as pharmaceutical, nutraceutical, and cosmetic industries. However, although DES has been touted as "green" solvents, several works proved that their potential toxicity should not be neglected. Using the premise of DES applicability in the cosmetic and pharmaceutical sectors, we chose two cell lines to work as a skin model (keratinocytes HaCaT and tumor melanocytes MNT-1), to assess DES cytotoxicity. The effect of three different hydrogen bond acceptors (HBA) ([Chol]Cl, [N₁₁₁₁]Cl and [N₄₄₄₄]Cl) and three different hydrogen bond donors (HBD) (hexanoic and butanoic acid, ethylene glycol, 1-propanol and urea) were

SUBMITTER: Macario IPE 

PROVIDER: S-EPMC6408470 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature