Rethinking Endothelial Dysfunction as a Crucial Target in Fighting Heart Failure.

ABSTRACT: Endothelial dysfunction is characterized by nitric oxide dysregulation and an altered redox state. Oxidative stress and inflammatory markers prevail, thus promoting atherogenesis and hypertension, important risk factors for the development and progression of heart failure. There has been a reemerging interest in the role that endothelial dysfunction plays in the failing circulation. Accordingly, patients with heart failure are being clinically assessed for endothelial dysfunction via various methods, including flow-mediated vasodilation, peripheral arterial tonometry, quantification of circulating endothelial progenitor cells, and early and late endothelial progenitor cell outgrowth measurements. Although the mechanisms underlying endothelial dysfunction are intimately related to cardiovas

SUBMITTER: Premer C 

PROVIDER: S-EPMC6408687 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature