Identification of co-expression modules and pathways correlated with osteosarcoma and its metastasis.

ABSTRACT:

Background

Osteosarcoma is the most common bone tumor that occurs in children.

Methods

To identify co-expression modules and pathways correlated with osteosarcoma and its clinical characteristics, we performed weighted gene co-expression network analysis (WGCNA) on RNA-seq data of osteosarcoma with 52 samples. Then we performed pathway enrichment analysis on genes from significant modules.

Results

A total of 5471 genes were included in WGCNA, and 16 modules were identified. Module-trait analysis identified that a module involved in microtubule bundle formation, drug metabolism-cytochrome P450, and IL-17 signaling pathway was negatively correlated with osteosarcoma and positively correlated with metastasis; a module involved in DNA replication was positively correlated

SUBMITTER: Wang JS 

PROVIDER: S-EPMC6408756 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature