Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study.

ABSTRACT:

Background

High background parenchymal uptake (BPU) on molecular breast imaging (MBI) has been identified as a breast cancer risk factor. We explored the feasibility of offering a short-term intervention of low-dose oral tamoxifen to women with high BPU and examined whether this intervention would reduce BPU.

Methods

Women with a history of high BPU and no breast cancer history were invited to the study. Participants had an MBI exam, followed by 30 days of low-dose oral tamoxifen at either 5 mg or 10 mg/day, and a post-tamoxifen MBI exam. BPU on pre- and post-tamoxifen MBI exams was quantitatively assessed as the ratio of average counts in breast fibroglandular tissue vs. average counts in subcutaneous fat. Pre-tamoxifen and post-tamoxifen BPU were compared with paired t tes

SUBMITTER: Hruska CB 

PROVIDER: S-EPMC6408779 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature