Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene.

ABSTRACT:

Background

Frizzled family members belong to G-protein coupled receptors and encode proteins accountable for cell signal transduction, cell proliferation and cell death. Members of Frizzled receptor family are considered to have critical roles in causing various forms of cancer, cardiac hypertrophy, familial exudative vitreoretinopathy (FEVR) and schizophrenia.

Results

This study investigates the evolutionary and structural aspects of Frizzled receptors, with particular focus on FEVR associated FZD4 gene. The phylogenetic tree topology suggests the diversification of Frizzled receptors at the root of metazoans history. Moreover, comparative structural data reveals that FEVR associated missense mutations in FZD4 effect the common protein region (amino acids 495-537) through a

SUBMITTER: Seemab S 

PROVIDER: S-EPMC6408821 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature