Genome-wide methylation is modified by caloric restriction in Daphnia magna.

ABSTRACT:

Background

The degradation of epigenetic control with age is associated with progressive diseases of ageing, including cancers, immunodeficiency and diabetes. Reduced caloric intake slows the effects of ageing and age-related disease in vertebrates and invertebrates, a process potentially mediated by the impact of caloric restriction on epigenetic factors such as DNA methylation. We used whole genome bisulphite sequencing to study how DNA methylation patterns change with diet in a small invertebrate, the crustacean Daphnia magna. Daphnia show the classic response of longer life under caloric restriction (CR), and they reproduce clonally, which permits the study of epigenetic changes in the absence of genetic variation.

Results

Global cytosine followed by guanine (CpG) methyl

SUBMITTER: Hearn J 

PROVIDER: S-EPMC6408862 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature