Adjuncts to Blood Component Therapies for the Treatment of Bleeding in the Intensive Care Unit.

ABSTRACT: Patients who are critically ill following surgical or traumatic injury often present with coagulopathy as a component of the complex multisystem dysfunction that clinicians must rapidly diagnose and treat in the intensive care environment. Failure to recognize coagulopathy while volume resuscitation with crystalloid or colloid takes place, or an unbalanced transfusion strategy focused on packed red blood cell transfusion can all significantly worsen coagulopathy, leading to increased transfusion requirements and poor outcomes. Even an optimized transfusion strategy directed at correcting coagulopathy and maintaining clotting factor levels carries the risk of a number of transfusion reactions including transfusion-related acute lung injury, transfusion-related circulatory overload, anaphyla

SUBMITTER: Levy JH 

PROVIDER: S-EPMC6408932 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature