Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk.

ABSTRACT: To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial differentiation was associated with widespread developmental remodeling of the chromosomal contact map and included interactions anchored in common variant sequences that confer heritable risk for schizophrenia. We describe cell type-specific chromosomal connectomes composed of schizophrenia risk variants and their distal targets, which altogether show enrichment for genes that regulate neuronal connectivity and chromatin remodeling, and evidence for coordinated transcriptional regulation and proteomic interaction of the participating genes. Developmentally r

SUBMITTER: Rajarajan P 

PROVIDER: S-EPMC6408958 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature