Chronic rhinosinusitis in elderly patients is associated with an exaggerated neutrophilic proinflammatory response to pathogenic bacteria.

ABSTRACT:

Background

Potential effects of aging on chronic rhinosinusitis (CRS) pathophysiology have not been well defined but might have important ramifications given a rapidly aging US and world population.

Objective

The goal of the current study was to determine whether advanced age is associated with specific inflammatory CRS endotypes or immune signatures.

Methods

Levels of 17 mucus cytokines and inflammatory mediators were measured in 147 patients with CRS. Hierarchical cluster analysis was used to identify and characterize inflammatory CRS endotypes, as well as to determine whether age was associated with specific immune signatures.

Results

A CRS endotype with a proinflammatory neutrophilic immune signature was enriched in older patients. In the overall cohort pat

SUBMITTER: Morse JC 

PROVIDER: S-EPMC6408962 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature