Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study.

ABSTRACT:

Introduction

The easily-imaged retinal microvasculature may reflect the brain microvasculature and therefore be related to dementia.

Methods

In a population-based study of 12,482 adults aged 50-73 years (22% African American), we estimated the relationship of retinal characteristics from fundus photography (1993-1995) with incident all-cause dementia (1993-1995 to 2011-2013) and with etiologic subtype of dementia/mild cognitive impairment (2011-13).

Results

A total of 1259 (10%) participants developed dementia over a mean 15.6 years. Moderate/severe (vs. no) retinopathy (hazard ratio [HR], 1.86; 95% confidence interval [CI]: 1.36-2.55) and central retinal arteriolar equivalent (narrowest quartile vs. widest three quartiles; HR, 1.26; 95% CI: 1.09-1.45) were associated

SUBMITTER: Deal JA 

PROVIDER: S-EPMC6408967 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature