Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery.

ABSTRACT:

Background & aims

Bile diversion to the ileum (GB-IL) has strikingly similar metabolic and satiating effects to Roux-en-Y gastric bypass (RYGB) in rodent obesity models. The metabolic benefits of these procedures are thought to be mediated by increased bile acids, although parallel changes in body weight and other confounding variables limit this interpretation.

Methods

Global G protein-coupled bile acid receptor-1 null (Tgr5^-/-) and intestinal-specific farnesoid X receptor null (Fxr^Δ/E) mice on high-fat diet as well as wild-type C57BL/6 and glucagon-like polypeptide 1 receptor deficient (Glp-1r^-/-) mice on chow diet were characterized following GB-IL.

Results

GB-IL induced weight loss and improved oral glucose tolerance in Tgr5^-/

SUBMITTER: Albaugh VL 

PROVIDER: S-EPMC6409186 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature