Prediction of Gene Expression Patterns With Generalized Linear Regression Model.

ABSTRACT: Cell reprogramming has played important roles in medical science, such as tissue repair, organ reconstruction, disease treatment, new drug development, and new species breeding. Oct4, a core pluripotency factor, has especially played a key role in somatic cell reprogramming through transcriptional control and affects the expression level of genes by its combination intensity. However, the quantitative relationship between Oct4 combination intensity and target gene expression is still not clear. Therefore, firstly, a generalized linear regression method was constructed to predict gene expression values in promoter regions affected by Oct4 combination intensity. Training data, including Oct4 combination intensity and target gene expression, were from promoter regions of genes with different

SUBMITTER: Liu S 

PROVIDER: S-EPMC6409355 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature