The Many Nuanced Evolutionary Consequences of Duplicated Genes.

ABSTRACT: Gene duplication is seen as a major source of structural and functional divergence in genome evolution. Under the conventional models of sub or neofunctionalization, functional changes arise in one of the duplicates after duplication. However, we suggest here that the presence of a duplicated gene can result in functional changes to its interacting partners. We explore this hypothesis by in silico evolution of a heterodimer when one member of the interacting pair is duplicated. We examine how a range of selection pressures and protein structures leads to differential patterns of evolutionary divergence. We find that a surprising number of distinct evolutionary trajectories can be observed even in a simple three member system. Further, we observe that selection to correct dosage imbalance c

SUBMITTER: Teufel AI 

PROVIDER: S-EPMC6409435 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature