Microstructured and Degradable Bacterial Cellulose⁻Gelatin Composite Membranes: Mineralization Aspects and Biomedical Relevance.

ABSTRACT: Bacterial cellulose (BC)⁻gelatin (GEL) membranes were processed by successive periodate oxidation and a freeze-thawing/carbodiimide crosslinking procedure, first facilitating a Schiff-base reaction among respective aldehyde and hydroxyl groups, and later GEL stabilization and microstructuring. The formation of highly microporous structures within the GEL portion, with significant differences between bottom and top, was elucidated, and pores in the 27.6 ± 3 µm⁻108 ± 5 µm range were generated, exceeding the threshold value of ~10 µm sufficient for cell trafficking. During a relatively short (6 h) exhaustion procedure in supersaturated simulated body fluid solution, the membranes accommodated the combination of biologically relevant minerals, i.e., flake-like octacalcium phosphate (OCP) and (

SUBMITTER: Gorgieva S 

PROVIDER: S-EPMC6409525 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature