A Single-Nucleotide Polymorphism of α_Vβ₃ Integrin Is Associated with the Andes Virus Infection Susceptibility.

ABSTRACT: The AndesOrthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression mod

SUBMITTER: Martinez-Valdebenito C 

PROVIDER: S-EPMC6409546 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature