PheWAS-Based Systems Genetics Methods for Anti-Breast Cancer Drug Discovery.

ABSTRACT: Breast cancer is a high-risk disease worldwide. For such complex diseases that are induced by multiple pathogenic genes, determining how to establish an effective drug discovery strategy is a challenge. In recent years, a large amount of genetic data has accumulated, particularly in the genome-wide identification of disorder genes. However, understanding how to use these data efficiently for pathogenesis elucidation and drug discovery is still a problem because the gene⁻disease links that are identified by high-throughput techniques such as phenome-wide association studies (PheWASs) are usually too weak to have biological significance. Systems genetics is a thriving area of study that aims to understand genetic interactions on a genome-wide scale. In this study, we aimed to establish two e

SUBMITTER: Gao M 

PROVIDER: S-EPMC6409623 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature