Preparation of Targeted Lignin⁻Based Hollow Nanoparticles for the Delivery of Doxorubicin.

ABSTRACT: Due to their exceptional absorption capacity, biodegradability, and non-toxicity, nanoparticles (NPs) from lignin have emerged as vehicles for inorganic particles and drug molecules. However, the method for preparing targeted lignin particles is still complex and lacks sufficient research. Herein, a succinct strategy was proposed for the preparation of targeted lignin-based drug delivery NPs to load Doxorubicin Hydrochloride (DOX). The lignin hollow NPs (LHNPs) were used as a platform for the preparation of targeted delivery material by incorporating magnetic NPs and folic acid (FA) via layer-by-layer self-assembling. The results showed that the surface of LHNPs was covered uniformly by Fe₃O₄ NPs and grafted with folic acid. The folic-magnetic-functionalized lignin hollow NPs (FA-MLHNPs) c

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6409628 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature