Novel Approaches for The Development of Live Attenuated Influenza Vaccines.

ABSTRACT: Influenza virus still represents a considerable threat to global public health, despite the advances in the development and wide use of influenza vaccines. Vaccination with traditional inactivate influenza vaccines (IIV) or live-attenuated influenza vaccines (LAIV) remains the main strategy in the control of annual seasonal epidemics, but it does not offer protection against new influenza viruses with pandemic potential, those that have shifted. Moreover, the continual antigenic drift of seasonal circulating influenza viruses, causing an antigenic mismatch that requires yearly reformulation of seasonal influenza vaccines, seriously compromises vaccine efficacy. Therefore, the quick optimization of vaccine production for seasonal influenza and the development of new vaccine approaches for p

SUBMITTER: Blanco-Lobo P 

PROVIDER: S-EPMC6409754 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature