Macrophages from Susceptible and Resistant Chicken Lines have Different Transcriptomes following Marek's Disease Virus Infection.

ABSTRACT: Despite successful control by vaccination, Marek's disease (MD) has continued evolving to greater virulence over recent years. To control MD, selection and breeding of MD-resistant chickens might be a suitable option. MHC-congenic inbred chicken lines, 6₁ and 7₂, are highly resistant and susceptible to MD, respectively, but the cellular and genetic basis for these phenotypes is unknown. Marek's disease virus (MDV) infects macrophages, B-cells, and activated T-cells in vivo. This study investigates the cellular basis of resistance to MD in vitro with the hypothesis that resistance is determined by cells active during the innate immune response. Chicken bone marrow-derived macrophages from lines 6₁ and 7₂ were infected with MDV in vitro. Flow cytometry showed that a higher percentage of macr

SUBMITTER: Chakraborty P 

PROVIDER: S-EPMC6409778 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature