DNA Methylation Patterns in the Social Spider, Stegodyphus dumicola.

ABSTRACT: Variation in DNA methylation patterns among genes, individuals, and populations appears to be highly variable among taxa, but our understanding of the functional significance of this variation is still incomplete. We here present the first whole genome bisulfite sequencing of a chelicerate species, the social spider Stegodyphus dumicola. We show that DNA methylation occurs mainly in CpG context and is concentrated in genes. This is a pattern also documented in other invertebrates. We present RNA sequence data to investigate the role of DNA methylation in gene regulation and show that, within individuals, methylated genes are more expressed than genes that are not methylated and that methylated genes are more stably expressed across individuals than unmethylated genes. Although no ca

SUBMITTER: Liu S 

PROVIDER: S-EPMC6409797 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature