Pipeline for the Rapid Development of Cytogenetic Markers Using Genomic Data of Related Species.

ABSTRACT: Repetitive DNA including tandem repeats (TRs) is a significant part of most eukaryotic genomes. TRs include rapidly evolving satellite DNA (satDNA) that can be shared by closely related species, their abundance may be associated with evolutionary divergence, and they have been widely used for chromosome karyotyping using fluorescence in situ hybridization (FISH). The recent progress in the development of whole-genome sequencing and bioinformatics tools enables rapid and cost-effective searches for TRs including satDNA that can be converted into molecular cytogenetic markers. In the case of closely related taxa, the genome sequence of one species (donor) can be used as a base for the development of chromosome markers for related species or genomes (target). Here, we present a

SUBMITTER: Kroupin P 

PROVIDER: S-EPMC6409974 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature