Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry.

ABSTRACT: Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made available. Broad-spectrum antivirals are drugs with the potential to inhibit infection by viruses from different groups or families, which may be deployed during outbreaks when specific diagnostics, vaccines or directly acting antivirals are not available. While pathogen-directed approaches are generally effective against a few closely related viruses, targeting cellular pathways used by multiple viral agents can have broad-spectrum efficacy. Virus entry, particularly clathrin-mediated endocytosis, constitutes an attractive target as it is used

SUBMITTER: Mazzon M 

PROVIDER: S-EPMC6410080 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature