A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions.

ABSTRACT: Post-traumatic stress disorder (PTSD) is an acquired psychiatric disorder with functionally impairing physiological and psychological symptoms following a traumatic exposure. Genetic, epigenetic, and environmental factors act together to determine both an individual's susceptibility to PTSD and its clinical phenotype. In this literature review, we briefly review the candidate genes that have been implicated in the development and severity of the PTSD phenotype. We discuss the importance of the epigenetic regulation of these candidate genes. We review the general epigenetic mechanisms that are currently understood, with examples of each in the PTSD phenotype. Our focus then turns to studies that have examined PTSD in the context of comorbid psychiatric disorders or associated social and beh

SUBMITTER: Blacker CJ 

PROVIDER: S-EPMC6410143 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature