Host Resistance, Genomics and Population Dynamics in a <i>Salmonella</i> Enteritidis and Phage System.

ABSTRACT: Bacteriophages represent an alternative solution to control bacterial infections. When interacting, bacteria and phage can evolve, and this relationship is described as antagonistic coevolution, a pattern that does not fit all models. In this work, the model consisted of a microcosm of Salmonella enterica serovar Enteritidis and φSan23 phage. Samples were taken for 12 days every 48 h. Bacteria and phage samples were collected; and isolated bacteria from each time point were challenged against phages from previous, contemporary, and subsequent time points. The phage plaque tests, with the genomics analyses, showed a mutational asymmetry dynamic in favor of the bacteria instead of antagonistic coevolution. This is important for future phage-therapy applications, so we decided t

SUBMITTER: Holguin AV 

PROVIDER: S-EPMC6410252 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature