Coalitional Game Theory Facilitates Identification of Non-Coding Variants Associated With Autism.

ABSTRACT: Studies on autism spectrum disorder (ASD) have amassed substantial evidence for the role of genetics in the disease's phenotypic manifestation. A large number of coding and non-coding variants with low penetrance likely act in a combinatorial manner to explain the variable forms of ASD. However, many of these combined interactions, both additive and epistatic, remain undefined. Coalitional game theory (CGT) is an approach that seeks to identify players (individual genetic variants or genes) who tend to improve the performance-association to a disease phenotype of interest-of any coalition (subset of co-occurring genetic variants) they join. This method has been previously applied to boost biologically informative signal from gene expression data and exome sequencing data but remains to be

SUBMITTER: Sun MW 

PROVIDER: S-EPMC6410388 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature