Cryptic Secondary Metabolites from the Sponge-Associated Fungus Aspergillus ochraceus.

ABSTRACT: The fungus Aspergillus ochraceus was isolated from the Mediterranean sponge Agelas oroides. The initial fermentation of the fungus on solid rice medium yielded 16 known compounds (4⁻19). The addition of several inorganic salts to the rice medium mainly influenced the accumulation of these secondary metabolites. Fermentation of the fungus on white bean medium yielded the new waspergillamide B (1) featuring an unusual p-nitrobenzoic acid as partial structure. Moreover, two new compounds, ochraspergillic acids A and B (2 and 3), which are both adducts of dihydropenicillic acid and o- or p-aminobenzoic acid, were isolated from the co-culture of the fungus with Bacillus subtilis. Compound 2 was also detected in

SUBMITTER: Frank M 

PROVIDER: S-EPMC6410417 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature