Pancreatic Progenitors and Organoids as a Prerequisite to Model Pancreatic Diseases and Cancer.

ABSTRACT: Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are characterized by their unique capacity to stepwise differentiate towards any particular cell type in an adult organism. Pluripotent stem cells provide a beneficial platform to model hereditary diseases and even cancer development. While the incidence of pancreatic diseases such as diabetes and pancreatitis is increasing, the understanding of the underlying pathogenesis of particular diseases remains limited. Only a few recent publications have contributed to the characterization of human pancreatic development in the fetal stage. Hence, most knowledge of pancreatic specification is based on murine embryology. Optimizing and understanding current in vitro protocols for pancreatic differentiation of ESCs and iPSCs con

SUBMITTER: Hohwieler M 

PROVIDER: S-EPMC6410438 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature