Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines.

ABSTRACT: Risk factors for hypertension consist of lifestyle and genetic factors. Family history and twin studies have yielded heritability estimates of BP in the range of 34-67%. The most recent paper of BP GWAS has explained about 20% of the population variation of BP. An overestimation of heritability may have occurred in twin studies due to violations of shared environment assumptions, poor phenotyping practices in control cohorts, failure to account for epistasis, gene-gene and gene-environment interactions, and other non-genetic sources of phenotype modulation that are suspected to lead to underestimations of heritability in GWAS. The recommendations of hypertension guidelines in major countries consist of the following elements: weight reduction, a healthy diet, dietary sodium reduction, incr

SUBMITTER: Kokubo Y 

PROVIDER: S-EPMC6410507 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature