Progress on norovirus vaccine research: public health considerations and future directions.

ABSTRACT:

Introduction

Noroviruses are the leading cause of foodborne illness worldwide, account for approximately one-fifth of acute gastroenteritis (AGE) cases globally, and cause a substantial economic burden. Candidate norovirus vaccines are in development, but there is currently no licensed vaccine.

Areas covered

Noroviruses cause approximately 684 million cases and 212,000 deaths per year across all age groups, though burden estimates vary by study and region. Challenges to vaccine research include substantial and rapidly evolving genetic diversity, short-term and homotypic immunity to infection, and the absence of a single, well-established correlate of protection. Nonetheless, several norovirus vaccine candidates are currently in development, utilizing virus-like particles (VL

SUBMITTER: Mattison CP 

PROVIDER: S-EPMC6410563 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature