Fate mapping reveals the age structure of the peripheral T cell compartment.

ABSTRACT: Accumulating evidence indicates that the immune system does not develop in a linear fashion, but rather as distinct developmental layers formed from sequential waves of hematopoietic stem cells, each giving rise to unique populations of immune cells at different stages of development. Although recent studies have indicated that conventional CD8⁺ T cells produced in early life persist into adulthood and exhibit distinct roles during infection, the developmental architecture of the peripheral T cell compartment remains undefined. In this study, we used a mouse model to permanently label CD8⁺ T cells produced during distinct windows of development and traced their history to generate fate maps of CD8⁺ T cells produced during different stages of life. We then u

SUBMITTER: Reynaldi A 

PROVIDER: S-EPMC6410819 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature