CD4⁺ T help promotes influenza virus-specific CD8⁺ T cell memory by limiting metabolic dysfunction.

ABSTRACT: There is continued interest in developing novel vaccine strategies that induce establish optimal CD8⁺ cytotoxic T lymphocyte (CTL) memory for pathogens like the influenza A viruses (IAVs), where the recall of IAV-specific T cell immunity is able to protect against serologically distinct IAV infection. While it is well established that CD4⁺ T cell help is required for optimal CTL responses and the establishment of memory, when and how CD4⁺ T cell help contributes to determining the ideal memory phenotype remains unclear. We assessed the quality of IAV-specific CD8⁺ T cell memory established in the presence or absence of a concurrent CD4⁺ T cell response. We demonstrate that CD4⁺ T cell help appears to be required at the initi

SUBMITTER: Cullen JG 

PROVIDER: S-EPMC6410826 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature