White shark genome reveals ancient elasmobranch adaptations associated with wound healing and the maintenance of genome stability.

ABSTRACT: The white shark (Carcharodon carcharias; Chondrichthyes, Elasmobranchii) is one of the most publicly recognized marine animals. Here we report the genome sequence of the white shark and comparative evolutionary genomic analyses to the chondrichthyans, whale shark (Elasmobranchii) and elephant shark (Holocephali), as well as various vertebrates. The 4.63-Gbp white shark genome contains 24,520 predicted genes, and has a repeat content of 58.5%. We provide evidence for a history of positive selection and gene-content enrichments regarding important genome stability-related genes and functional categories, particularly so for the two elasmobranchs. We hypothesize that the molecular adaptive emphasis on genome stability in white and whale sharks may reflect the combined selective pressur

SUBMITTER: Marra NJ 

PROVIDER: S-EPMC6410855 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature