Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.

ABSTRACT: Each year influenza virus infections cause hundreds of thousands of deaths worldwide and a significant level of morbidity with major economic burden. At the present time, vaccination with inactivated virus vaccine produced from embryonated chicken eggs is the most prevalent method to prevent the infections. However, current influenza vaccines are only effective against closely matched circulating strains and must be updated and administered yearly. Therefore, generating a vaccine that can provide broad protection is greatly needed for influenza vaccine development. We have previously shown that vaccination of the major surface glycoprotein hemagglutinin (HA) of influenza virus with a single N-acetylglucosamine at each of the N-glycosylation sites [monoglycosylated HA (HA_mg

SUBMITTER: Tseng YC 

PROVIDER: S-EPMC6410868 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature