Tissue self-organization based on collective cell migration by contact activation of locomotion and chemotaxis.

ABSTRACT: Despite their central role in multicellular organization, navigation rules that dictate cell rearrangement remain largely undefined. Contact between neighboring cells and diffusive attractant molecules are two of the major determinants of tissue-level patterning; however, in most cases, molecular and developmental complexity hinders one from decoding the exact governing rules of individual cell movement. A primordial example of tissue patterning by cell rearrangement is found in the social amoeba Dictyostelium discoideum where the organizing center or the "tip" self-organizes as a result of sorting of differentiating prestalk and prespore cells. By employing microfluidics and microsphere-based manipulation of navigational cues at the single-cell level, here we uncovered a previously

SUBMITTER: Fujimori T 

PROVIDER: S-EPMC6410881 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature