The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma.

ABSTRACT:

Background

Virtually all low-grade gliomas (LGGs) will progress to high-grade gliomas (HGGs), including glioblastoma, the most common malignant primary brain tumor in adults. A key regulator of immunosuppression, fibrinogen-like protein 2 (FGL2), may play an important role in the malignant transformation of LGG to HGG. We sought to determine the mechanism of FGL2 on tumor progression and to show that inhibiting FGL2 expression had a therapeutic effect.

Methods

We analyzed human gliomas that had progressed from low- to high-grade for FGL2 expression. We modeled FGL2 overexpression in an immunocompetent genetically engineered mouse model to determine its effect on tumor progression. Tumors and their associated microenvironments were analyzed for their immune cell infiltration.

SUBMITTER: Latha K 

PROVIDER: S-EPMC6410946 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature